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Reactive arthritis (ReA), formerly known as Reiter syndrome, is inflammation of the joints and tendon, often accompanied by inflammation of the eye’s conjunctiva or iris and the mucous membranes, such as those of the mouth and genitourinary tract. It is an auto immune Sero-negative arthritis which develops in response to an infection of the GI or GU tracts.

The classic triad of symptoms: conjunctivitis, urethritis, and arthritis

  • Enthesitis: tenderness at the insertion of the (Achilles) tendon


A 23-year-old man has a 2 week history of intermittent diarrhea, urethral discharge, and pain in the left knee. He is sexually active with multiple partners. He has several oral ulcers, iritis, a scaly papular rash on palms and soles. Genito urinary examination shows multiple superficial ulcers on the glans penis. The results of gram-stain and culture of urethral discharge are negative. Rheumatoid factor is not present.



Antibiotic against Chlamydia: Doxycycline and azithramycine

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